Orally, about 1 h before intercourse, 50 mg. Taking into account efficacy and tolerability, the dose may be increased to 100 mg or decreased to 25 mg. The maximum daily dose is 100 mg, the maximum recommended frequency of administration is once a day.
Erectile dysfunction, impotence is an erectile dysfunction in which the volume, hardness, and erectness of a man's penis are insufficient for sexual intercourse.
Viagra can contain sildenafil (Sildenafil) in concentrations of 25, 50 or 100 mg.
In addition to sildenafil the drug contains: microcrystalline cellulose, calcium hydrophosphate, croscarmellose sodium, magnesium stearate.
Opadry blue and clear are used to make the film coating of the tablets. The composition of Viagra does not differ depending on the concentration of the active ingredient.
The natural mechanism of erection is related to the release during sexual stimulation
Sildenafil is a potent and selective inhibitor of cGMP-specific FDE-5 (phosphodiesterase-5) in the cavernous body, where FDE-5 plays an important role in the breakdown of cGMP.
The effect of the substance on erectile function is peripheral: the drug does not have a direct relaxing effect on the isolated cavernous body of the man, while powerfully enhancing the relaxing effect of nitric oxide on it.
Sexual arousal is required for sildenafil to have the necessary therapeutic effect.
TCmax (time of reaching maximum plasma concentration) when taking sildenafil orally on an empty stomach is from 0.5 to 2 hours, bioavailability ranges from 25 to 60%.
Sildenafil is metabolized in the liver by microsomal isoenzymes of the cytochrome system.
The drug description states that Viagra is intended to treat erectile dysfunction resulting from vascular or nervous disorders and is defined as the inability to achieve and maintain an erection in the penis for the time required for successful intercourse.